NURS 216 Lecture Notes - Lecture 3: Pancreatic Lipase Family, Drug Metabolism, Lactose Intolerance
15 Sep 2019
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Document Summary
Protein gastric pepsin, pancreatic enzymes creates peptides (amino acid chains) transports across intestinal mucosa. Bowel innervation lingual lipase: pancreatic lipase fatty acids and triglycerides. Enteric nervous system: controls gastric motility actions. Caused by infectious organisms, food intolerance, drugs, intestinal disease or medical treatments. Non inflammatory watery and non bloody stools disruption of normal absorption or secretory process periumbilical cramps, bloating and nausea or vomiting. Inflammatory caused by infections such as shigella, salmonella, c. difficile, e. coli etc. affects colon/large intestine can result in dehydration fever and bloody diarrhea (dysentery) left lower quadrant cramps, urgency and tenesmus (feeling of incomplete defecation) 70%bioavailability little 1st pass metabolism losses binds directly to bacteria in the gi. Phase i metabolism with active metabolites less potent than the original drug. Cyp inhibitor renal excretion and some biliary (half life is 4 hours: difficile. Releases enterotoxin (toxin a) and cytotoxin (toxin b) Causes gi cells to burst or die (pseudomembranous colitis)
