NURS 216 Lecture Notes - Lecture 1: Lipid Bilayer, Drug Metabolism, Membrane Transport
3 Sep 2019
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3 categories: drugs/medications (chemical agents, biologic: are naturally produced in animal cells. Hormones, antibodies, blood products, genetic treatment modalities: natural health product (nph): naturally occuring and used as an adjunct. Evaluation: assessing drug action and side effects. Always include patient education in nursing care. Pharmacokinetics: the movement of drugs across a lipid bilayer. 4 phases: absorption, distribution, metabolism, excretion (adme) affected by charge (ionization), ionized means polar and non-ionized non-polar (not charged) can be lipophilic o hydrophilic different sizes affect movement different modes of membrane transport. Diffusion: requires lipophilicity, uncharged/non-ionized particles and a smaller particle size (such as gasses) Osmosis: only the solvent moves, no atp is required and uses non-ionized particles (such as water) saturable hydrophilic large molecules ionized amino acids, electrolytes. Facilitated diffusion: no atp required, with molecules moving from high concentrations to low concentrations using specialized channels and protein carriers saturable hydrophilic larger molecules ionized water, glucose, soe electrolytes (such as na+)
