NURS 116 Lecture Notes - Lecture 12: Corynebacterium Diphtheriae, Pseudomonas Aeruginosa, Neisseria Gonorrhoeae
28 Feb 2019
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Document Summary
Infection: invasion and multiplication of microorganisms in body tissues, can be apparent or result in cellular injury due to competitive metabolism, toxins, intracellular replication or antigen-antibody response. First line - skin, mucous membrane, normal microbiota. Second line of defence - nk/phagocytic cells, inflammation, fever, antimicrobial substances. Third line of defence - specialized lymphocytes, t cells and b cells, antibodies. Invasin - proteins or enzymes act against host by breaking down the first-line defences of the host body. Spreading factors - most common type of invasins, which help pathogens to invade intercellular matrices. Non-spreading factor - help pathogens breach non-phagocytic host cell. Local infection: pathogens are limited to a small area of the body. Focal infection: systemic infection that begins as a local infection. Sepsis: toxic inflammatory condition from the spread of microbes , especially toxins, from a focus of infection. Septicemia: blood poisoning, growth of bacteria in the blood. Primary infection: acute infection that caused the initial illness.
