NURS 116 Lecture 9: Pathophisiolgy of Autoimmune Disorders
6 Feb 2019
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A: absolute suppression is needed in order to prevent rejection, and should be the lowest risk possible. Calcineurin inhibitors - most potent of the immunosuppressants (lymphocytes, b cells and t. Immunosuppressants have a very small therapeutic index due to its toxicity. Women are more likely to suffer from autoimmune diseases than men. Myasthenia gravis - the blocking of complement activation and crosslinking leads to inactivated action potential in the neuromuscular junctions. Type ii - systemic lupus erythematosus, rheumatoid arthritis. Type iv - diabetes mellitus i, pasoriasis, celiac disease. *mainly affects the muscles and nervous system, usually related to some bacterial infection. Damage from igg or igm (cell-surface or matrix antigen) Involves classical complement pathway, phagocytosis via fcr and complement receptor, Can either control symptoms (bb/ccb) of controlling the hyperthyroidism itself. Thinomides (prototype propylthiouracil) - can be given as titration or block and replace , (thionamides) but can cause agranulocytosis, with a 50% disease remission.
