NEURO410 Lecture Notes - Lecture 13: Positron Emission Tomography, Dementia, Antiphospholipid Syndrome
12 Oct 2016
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Lecture 2: hd: clinical (feb. 25/ 16) autosomal dominant and 100% penetrance. 5-10% of affected individuals (not as common) deaths 15-20 yr after symptom onset. 5-10 / 100,000 population about 200-400 affected individuals. Irregular, unpredictable, purposeless, rapid movements that flow randomly from one body part to another: neurological sign: abnormality that indicates a particular part of the nervous system but not precise for any diagnosis (only a sign) Neuroacanthocytosis: rare: blood abnormalities in addition to neurological conditions. Motor dysfunction backwards pt takes additional steps to compensate. Chorea is usually the earliest sign: initially fingers, toes, face and progressive. Motor impersistence: inability to maintain sustained muscle contraction (ie eye close) Impaired initiation of saccades: fix from one object to another = difficult. Progressiv incoordination, unsteady, immobile, dysarthria (speech), dysphagia (swallow) In some pts, other features may appear first, but motor signs eventually appear in all.
