NEURO410 Lecture Notes - Lecture 11: Neurofibrillary Tangle, Psen1, Pyramidal Cell
12 Oct 2016
School
Department
Course
Professor
Document Summary
Lecture 11a: neuronal transplantation and its implications in pd (feb. 8 2016) Most neurons must carry out their fxn for an entire life as they are not replaced if damaged by lesion or ndd: esp neurons of cns = not replaced. Cell replacement technique represents one of the advanced methods by which one can ameliorate dysfunction of the lesioned or damaged brain: these techniques are not cures, but attenuate the ongoing degeneration and ameliorates the behavioural dysfunction. It has clinical implications in ndd like ad and pd (no adequate medical treatments available) Can not just transplant neurons from one area to another (will not survive) Donor age: transplanted tissues survive best when they are from active stage of embryogenesis. Host age: old age drastically reduces survival and fiber outgrowth of graft. Vascularization: development of adequate blood supply to graft = one of the most important factors determining graft survival. If place graft next to csf (exp), survival is much higher.
