MMI436 Lecture Notes - Lecture 8: Eosinophil Cationic Protein, Eosinophil Peroxidase, Degranulation
4 Apr 2016
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Document Summary
Eosinophils first described in 1879 by paul ehrlich, noted that they stained with acidophilic dyes. Released into the peripheral blood in a mature state. Capable of being activated and recruited into tissues mostly driven by interleukin-5 and eotaxin chemokines. Short half life in blood : ~18 hours. Then migrate to thymus or gi tract where they reside under homeostasis 2. Recruited to and activated in lung tissue as part of the pathophysiology of asthma, contribute to airway dysfunction and tissue remodelling. Human eosinophil granules contain four major proteins: eosinophil peroxidase, major basic protein (mbp) and the ribonucleases eosinophil cationic protein (ecp) and eosinophil-derived neurotoxin (edn) Piecemeal degranulation is now accepted as the most commonly observed physiological form of eosinophil degranulation. Established acute infection with the rodent pneumovirus,(pvm- pneumonia virus of mice), in 3 distinct mouse models of th2 cytokine-driven asthmatic inflammation.
