IMIN405 Lecture Notes - Lecture 3: Damage-Associated Molecular Pattern, Endosome, Cx3Cl1

• School: University of Alberta
• Department: Immunology and Infection
• Course: IMIN405
• Professor: James Stafford

Document Summary

Pamps and prrs: non-self recognition, also inflammation and tissue damage. Immune cells sense the presence of pathogens and activate inflammatory responses. Classical pamps: peptidoglycan, lps, lta, bacterial or viral dna. Drosophila toll signaling pathway: changes in structure for a response, there"s the human tlr. Placing the right receptor in the right spot. And host rna should not be in the endosome, but there are receptors for rna. Changes in amino aicds could prevent detection of pamp. Methylated cpg dna, host, is not recognized, but microbial is, ends in ifn-a and tnf dsrna is not common in the cytoplasm from host cell: signature. Trauma leads to barrier damage, exposes the immune system to pamps. Immune response to clear pathogen but not too much you destroy host. Protect body from infection but also heal, pamp to damp. Self vs non self: then from self look if healthy. C5a: soluble factor that can enhance or inhibit cell migration.