IMIN200 Lecture Notes - Lecture 2: Teichoic Acid, Antimicrobial Peptides, Molecular Mimicry

• School: University of Alberta
• Department: Immunology and Infection
• Course: IMIN200
• Professor: Mario Feldman

Document Summary

Bacterial strategies to overcome the host immune response response. Bacteria don"t have a second chance to give a first impression 2 outer membrane with all the lethal poly saccharides everything on the peptidoglycan. Peptidoglycan structure and function connected by peptides peptide is common in all bacteria - not much variation. Only a few variation of sugartsd - they"re always the same. Essential for bacteria (present in almost all bacteria) Main functions: provide stability against osmotic imbalance, permeable barrier. Its synthesis is the target of penicillin and other antibiotics. Lps most common among gram-ve can recognize by immune system. Nam always the same peptides lots of d aa. Therefore our immune system will detect this. 2 kinds of struture how imune system detects it: Tlr recognize different pamps in bacteria and activate different cascades depending on which bacteria - they will interact with diff receptors so we know which response to make with very specific receptors.