IMIN200 Lecture Notes - Lecture 11: Campylobacter Jejuni, Helicobacter Pylori, Campylobacter

• School: University of Alberta
• Department: Immunology and Infection
• Course: IMIN200
• Professor: Mario Feldman

Document Summary

1 lives in intestines, causes diarrhea causes paralysis. Campylobacter species are commensal in chickens, cattle and pigs, colonizing the lower gastrointestinal tract. 42 c and provides a low oxygen (microaerobic) environment optimal for growth of campylobacter. 2 eating contaminated chickens chicken body temp is 42 degrees celcius micro aerobic => preferes low oxygen. Campylobacteriosis: the disease caused by causes bloody / watery diarrhea. Campylobacter species: most common cause of bacterial gastroenteritis, persistent bloody or watery diarrhea, precursor to acute peripheral neuropathies. => coat itself with antigens by avoiding the immune system. => therefore, will make antigens that will attack our nerves. The campylobacter jejuni lifecycle forming biofilms => therefore able to survive in more harsh conditions found predominantly in chicken flies contaminating poultry hosues humans really suscetpinle to campylobacter phages. => selective pressure for why campylbactor have to change their membrane. Factors important for virulence: los (mimicry, flagella (like t3ss, capsule, protein glycosylation.