CHEM263 Lecture Notes - Lecture 5: Dengue Virus, Hiv Vaccine, Fc Receptor

• School: University of Alberta
• Department: Chemistry
• Course: CHEM263
• Professor: John Brownell

Document Summary

Know when a virus is susceptible to a neutralizing antibody. Know how the test for aids is done. Understand what is happening to the epitope during escape from neutralizing antibodies. Review the features of the hiv envelope protein that make it resistant to neutralizing antibodies. Parts of this molecule look like self protein. This makes mounting an immune response to it risky due to autoimmunity. Understand that many of the processes that would normally eliminate the virus, assist in helping it infect macrophages, like fc receptor mediated uptake, or complement receptor mediated uptake. Think about why the gp120 hiv vaccine failed. Think also about makes the canadian vaccine now in trials, very promising. How can previous exposure like dengue virus (or sometimes a vaccine) help the virus gain entry to the cells. What are the polymerases used, and packaging requirements for +strand and ve strand.