BIOL207 Lecture Notes - Lecture 14: Gene Mapping, Genetic Marker, Oogenesis
13 Oct 2013
School
Department
Course
Professor
Document Summary
Crossover happens in almost all meiosis processes. Crossovers are detectable if one of the parents are heterozygous for 2+ gene: coupling configuration. Dominant alleles beside one another: repulsion configuration. Crossovers can be quantified w/ test cross: crossed w/ [ab/ab] for autosomal, crossed w/ [ab/y] for sex-linked (on x-chromosome) Human chr # 12: spermatogenesis crossover frequency is less than oogenesis. The gene map for human chromosome 12 is larger for females than it is for males: the frequency of crossovers occurring is proportional to the length of the gene map. If two genes are 70mu apart, the rf is 50% not 70% Genetic marker = detectable mutation of a known gene. Gene mapping via several two-point test crosses. We know that the rf between m and a is 50% (given: so we know that it is either on the same chromosome but. 50+ mu away or on the second chromosome.
