BIOCH410 Lecture Notes - Lecture 3: Elk1, Signal Transducing Adaptor Protein, Insulin Receptor
12 Feb 2020
School
Department
Course
Professor
Document Summary
Egf acts on its cognate receptor egfr. Phosphotyrosine residues acts as docking sites for domains like sh2. Sh3 domains can bind to proline rich regions. Once bonded to grb, sos can regulate activity of raw. When ras is bound to gdp it is o . When bound to gtp it is on state. Sos enables dislocating of gd and binding of gtp. Gap stimulate hydrolysis of gtp. deactivates ras. Ras is important as an activation of raf (kinase) When raf is activated it activates malk. Raf is a kinase that activates other kinase. Out of one molecule of egp you can have many di erent kinds of kinases activated. It is a kinase for phospholipids not of proteins. Once pi3k is recruited to cell membrane to attach to ras, it can in uence activity of akt. Akt is regulated by pi3k by a mechanism = isulin action has something to do with ras.
