BIOCH200 Lecture Notes - Phosphorylation, Gluconeogenesis, Enzyme

• School: University of Alberta
• Department: Biochemistry
• Course: BIOCH200
• Professor: Walter Dixon

Document Summary

24, 2014: enzyme regulation, *irreversible steps are usually regulated, *reversible steps are not enzymatically regulated; but enzymes present to help the reaction along. *rate-limitting step: is an irreversible step of the pathway that determines the overall rate: metabolic inhibition, *the production of a product leads to its own inhibition. By inhibiting the enzyme that converts the previous substrate into the said product. *this is called product inhibition because it is the product that inhibits: *feedback inhibition. *the presence of a product inhibits that pathway that leads to its creation this is to save energy (you don"t want to make a whole lot of intermediates and then not have anything to do with them . This is a waste of energy therefore it would be better to shut down this pathway until the [product] goes back down: metabolic activation, *upstream metabolites may cause the activation of an enzyme downstream that produces another metabolite.