BIOCH200 Lecture Notes - Lecture 20: Oxidative Phosphorylation, Flavin Mononucleotide, Atp Synthase
16 Apr 2018
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22. 03. 18 lec 20 breaking phosphoanhydride bond: water: hydrolysis, oh group like that in glucose: not much of hydrolysis. Phosphocreatine + adp + h+ -> creatine + atp: phosphocreatine: store of energy in cell, atp made without oxygen which makes it faster while using etc and oxygen makes it slow. Supplements of creatine helps to replenish phosphocreatine (muscle contraction is powered for. Phosphocreatine has a phosphoanhydride bond (high energy bond). Both creatine and phosphate are stabilised by resonance. Protein kinase only phosphorylates protein: add on a phosphate. When need atp, the above reaction goes forward. While relaxing, recovering etc starts to work so reaction goes forward. 2 enzymes regulated in the same manner: synchrous if i break sugar, i will stop making sugar. In order to avoid reversible reaction: bypass/replace, put in energy. This depends on what we do to the irreversible reactions. We need 2 molecules of nadh/fadh2 because we cannot reduce half a molecule of oxygen.
