BIOCH200 Lecture Notes - Lecture 1: Pyruvic Acid, Fructose, Hexokinase

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skycaribou653

9 Dec 2017

School

University of Alberta

Department

Biochemistry

Course

BIOCH200

Professor

Jonathan Parrish

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Document Summary

Glycolysis is a catabolic and anaerobic pathway that converts one molecule of glucose to 2 molecules of pyruvate. In the process it generates atp and nadh from oxidation of the metabolites. Glycolysis taken place in the cytosol through a series of 10 reactions. In the process, one glucose is broken down to two pyruvate molecules. The reaction has two stages: energy investment: atp is consumed to activate glucose. All stages are 6 carbon sugars: energy pay-out: atp is produced and nadh. Regulated steps in glycolysis: glucose +atp glucose-6-phosphate + adp + h+ (enzyme: hexokinase, frustose-6-phosphate +atp fructose 1,6-bisphosphate +adp+ h+ (enzyme: Phosphofructokinase-1: phosphoenolpyruvate + adp + h+ pyruvate +atp (enzyme: pyruvate kinase) Atp consuming stages: (2 atp used in total: glucose to glucose-6-phosphate, fructose-6-phosphate to fructose bisphosphate. Atp generating stage: glyceraldehyde-3-phosphate + nad+ +pi 1,3-bisphosphoglycerate +nadh + h, 1,3-bisphosphoglycerate + adp 3-phosphoglycerate + atp, phosphoenolpyruvate + adp +h+ pyruvate + atp.

Related Questions

The complete conversion of a molecule glucose to six molecules of carbon dioxide via glycolysis and the Krebs cycle requires 19 reactions. Put the reactions that are given below in the proper order, beginning with the phosphorylation of glucose to form glucose-6-phosphate and ending with the oxidation of malate to form oxaloacetic acid.

1) 1,3-bisphosphoglycerate + ADP --> 3-phosphoglycerate + ATP
2) fumarate + H₂O --> malate
3) isocitrate + NAD⁺ --> alpha-ketoglutarate + NADH + H⁺ + CO₂
4) phosphoenol pyruvate + ADP --> pyruvate + ATP
5) Succinyl-CoA + GDP + P_i --> succinate + GTP + CoASH
6) glyceraldehyde 3-phosphate + NAD⁺ + P_i --> 1,3-bisphosphoglycerate + NADH + H⁺

Thank you for the help!

tealleopard702

QUESTION 1

Which of the following is the correct order of the three stages of cellular respiration?

	a.	Krebs cycle, glycolysis, electron transport
	b.	electron transport, glycolysis, Krebs cycle
	c.	Krebs cycle, electron transport, glycolysis
	d.	glycolysis, Krebs cycle, electron transport
	e.	electron transport, Krebs cycle, glycolysis

1 points

QUESTION 2

Consider a bacterial cell that performs anaerobic respiration. If that bacterial cell had access to six molecules of glucose to use, how many ATP molecules would it be able to produce?

	a.	2
	b.	34
	c.	36
	d.	6
	e.	12

1 points

QUESTION 3

The oxygen that organisms need to live is used exclusively in which of the following metabolic pathways?

	a.	Electron transport chain
	b.	Anaerobic respiration
	c.	Glycolysis
	d.	Krebs cycle
	e.	ATP-Synthase

1 points

QUESTION 4

The electron transport chain uses the energy in NADH and FADH₂ to pump H⁺ ions from the matrix to the innermembrane space. The H⁺ gradient is then used to power ATP-Synthase. Enough H⁺ is pumped from the energy in a molecule of NADH to produce ______ ATP molecules, while enough H⁺ is pumped from the energy in a FADH₂ molecule to produce ______ ATP molecules.

	a.	three; two
	b.	three; three
	c.	two; two
	d.	two; three

1 points

QUESTION 5

Which of the following list contains only products of cellular respiration?

	a.	glucose, oxygen, ADP
	b.	ATP, carbon dioxide
	c.	oxygen, ADP, carbon dioxide
	d.	ATP, glucose, oxygen
	e.	glucose, ATP

1 points

QUESTION 6

What powers the enzyme ATP-Synthase?

	a.	NADH molecules
	b.	oxygen (O₂)
	c.	ATP
	d.	NADH and FADH₂ molecules
	e.	The H⁺ gradient between the matrix and inner-membrane space

1 points

QUESTION 7

Organisms exist which are able to survive using only glycolysis (i.e. without using oxidative phosphorylation).

True

False

1 points

QUESTION 8

Each ADP molecule contains ________ phosphates, and each ATP molecule contains ________ phosphates.

	a.	three; three
	b.	two; two
	c.	one; two
	d.	two; three
	e.	one; three

1 points

QUESTION 9

Adding a phosphate group to ADP to form ATP is an endergonic reaction.

True

False

1 points

QUESTION 10

The majority of ATP produced during cellular respiration is produced during glycolysis.

True

False

1 points

QUESTION 11

Glycolysis occurs:

	a.	on enzymes located in the inner-membrane.
	b.	in the cytosol.
	c.	in the inner-membrane space.
	d.	in the nucleus of the cell.
	e.	in the matrix of mitochondria.

1 points

QUESTION 12

Muscle soreness associated with strenuous exercise is due to:

	a.	the production of alcohol during anaerobic respiration.
	b.	a buildup of lactic acid.
	c.	an excessive amount of ATP that builds up during exercise.
	d.	the large amounts of CO₂ building up in the muscle.

1 points

QUESTION 13

A required reactant for glycolysis is:

	a.	the electron transport chain.
	b.	carbon dioxide.
	c.	oxygen.
	d.	NAD+.
	e.	mitochondria.

1 points

QUESTION 14

NADH is produced in all of the following except:

	a.	the electron transport chain.
	b.	the Krebs cycle.
	c.	glycolysis.

BIOCH200 Lecture Notes - Lecture 1: Pyruvic Acid, Fructose, Hexokinase

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