BIOCH200 Lecture 31: BIOCHEM 200 - Lecture #31 - Citric Acid Cycle
15 Dec 2016
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Biochem 200 - lecture #31 - citric acid cycle. The purpose of aerobic catabolism is to capture the energy in biological fuel molecules and use it to make atp. Oxidation of acetyl-coa by the citric acid cycle: acetyl coa comes from many sources like carbs, fatty acids and amino acid catabolism, reactions of the cac. Acetyl coa (c2) condenses with oxaloacetate (c4) to make citrate (c6) Substrate of the 1st reaction, product of the last reaction. **3 nadh, 1 fadh2(qh2), 1 gtp** made. Occurs in the mitochondrial matrix (eukaryotes: aerobic. O2 reduction to reoxidize nadh and fadh2: cofactors interact with complex i, appropriate proteins are found in the mitochondrial matrix here, reactions can potentially go either direction. Oxidizes acetyl coa co2 exclusively from glucose: acetyl coa generated by (catabolic) metabolism of many compounds (not. Generates high-energy products: nadh, fadh2/qh2, gtp atp (energetically equivalent) Reaction 1: catalyzed by citrate synthase: condensation of acetyl coa and oxaloacetate, irreversible, regulated, product: citrate.
