BIOCH200 Lecture Notes - Lecture 12: Globular Protein, Protein Structure, Entropy
4 Oct 2016
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Biochem 200 - lecture #12 - protein structure pt. Hydrophobic interactions and protein 3d shape in a soluble globular proteins: hydrophobic side chains are most likely to be found in the interior of a globular protein. Allows for an entropic advantage: hydrophilic side chains are most likely to be found on the surface of a globular protein. Spread out along the surface: **irregular structures are most likely to be found near the surface of a globular protein** This is because the structure does not satisfy the h bond. Requirements so it forms h bonds with water. If it were in the core, this would not be able to occur. Regular 2 structure found in the interior of folded proteins: loops tend to be located on the surface, core is rich in regular 2 structure, while irregular 2 structure are on surface.
