NURS 3550H Lecture Notes - Lecture 2: Interferon Type I, Cytostasis, Immunotherapy
15 Nov 2018
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Document Summary
Review of mechanism of medication site of action in the body; agonist or antagonist (discussion led by facilitators, input from group) Naturally occurring glycoprotein with antiviral, antiproliferative, and immunomodulatory effects. Naturally produced in response to viral invasion and other biological inducers. Inhibits the migration of proinflammatory leukocytes across bbb, preventing these cells from reaching neuros in cns. Manufactured using recombinant dna, contains 165 amino acids and has no glycoproteins (differs slightly) Suppress t-helper cell activity: review of therapeutic effect how does the drug treat the illness? (discussion led by facilitators, input from group) Modify the disease process, treat acute relapses and manage symptoms, does not cure ms. Approved for relapsing forms of ms (those with relapsing- remitting ms benefit most) Dec. frequency and severity of attacks, reduce # and size of mri detectable lesions, and delay progression of disability. Interferon beta is an immunomodulator therefore it is the preferred choice compared to immunosuppressants.
