MBB 342 Lecture Notes - Lecture 8: Tandem Repeat, Cytogenetics, Synapsis

• School: Simon Fraser University
• Department: Molec Biol & Biochem
• Course: MBB 342
• Professor: Gwylim Haynes

Document Summary

Genetic variation/evolution: different sources, horizontal transfer, xenologs, gene loss/duplication/structural variation (big and small) Lots of mutations/changes, there will be some bad ones: comes with negative consequences, small changes, ex. Tandem repeats: microsatellites, 5 -50 repeats, big changes, ex. More common for copy number polymorphism: some are tolerant to variation, some are extremely intolerant, depends on the function of the gene. Genome-wide structural variation: hybridization, can use array based methods (not too common anymore, look through slides, single molecular analysis, sequence-based approached. In the circular thing, 3000bp: when you map is, there"s only 1000bp. Indicates 2000bp insertion: when you map, there"s 6000bp. Snps and snvs: snv, single nucleotide variants, new/rare: mutations, common: polymorphisms. Insertions/deletions (small: microsatellite alterations, aneuploidies (+/- entire chromosomes, shtructual variations (large, common variation, read up, bottle neck, sudden decrease in population, followed up bounceback, can cause weird things with allele frequency.