HSCI 212 Lecture Notes - Lecture 7: Mycobacterium Avium-Intracellulare Infection, Shingles, Cytotoxic T Cell

• School: Simon Fraser University
• Department: Health Sciences
• Course: HSCI 212
• Professor: Nienke Van Houten

Document Summary

Although rate of new infections declined throughout most of 1990s, it is now rising again (false sense of security in richer nations and relaxation of precautions to prevent infection) 1/3 of 33 million hiv-infected have developed aids; spread of aids in sub-saharan africa. Found in blood, semen, saliva, vaginal secretions, and breast milk; in both free and inside infected. Wbcs; sufficient #s must be transmitted to target cells to establish an infection. Break in protective membranes of body large enough to allow entry of hiv. Describe the virus and the lifecycle of hiv. Understand the associations between viral lifecycle and treatment challenges. Reverse transcriptase uses cellular trna as primer to transcribe dsdna; lots of errors leads to (cid:373)utatio(cid:374)s, (cid:449)hi(cid:272)h (cid:373)ake it hard to de(cid:448)elop a (cid:448)a(cid:272)(cid:272)i(cid:374)e or for a(cid:374)ti(cid:271)odies to (cid:862)(cid:272)at(cid:272)h up(cid:863) Describe haart drugs and their mode of action. Cocktail of antiviral drugs: nucleoside analogs, protease inhibitors, and reverse transcriptase inhibitors.