HSCI 212 Lecture Notes - Lecture 10: Macrophage, Antigen, Gp41
10 Apr 2018
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Document Summary
Capsid: protein coat which provides protection of the rna = function. Reverse transcriptase: viral enzyme that transcribes ssrna template to make a cdna intermediate. If wanted to combat hiv w/ a drug good place to start by stopping reverse transcriptase from working reverse transcriptase inhibitors. Integrase: viral enzyme that catalyzes incorporation of cdna into the host cell genome: breaks host cell genome, insert double stranded cdna into host gene, then repair break so it becomes integrated into the host gene. Envelope proteins: embedded within the envelope/ viral membrane (gp120, docking protein interacts with the host cell to allow fusion and entry), (gp41, transmembrane protein allows complex to become stabilized within the viral membrane), Accessory proteins: vif, vpr, nef, p7, vpu: little proteins also encoded by hiv, job is to shut off innate immune response.
