HSCI 130 Lecture Notes - Lecture 21: Hiv Vaccine, Rna Virus, Lipid Bilayer
16 Jun 2016
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Lecture by mark brockman, ph. d. (associate professor and canada research chair faculty of hs) 1. 2 million deaths due to aids as of 2014. Typically young women are the major risk group currently. Successes for treatment currently are the arv therapy (anti-retroviral drugs: 33% reduction in infected (2001-2014, 39% reduction in deaths (2001-2014, 52% reduction in inborn infections (2001-2014) Hiv is a single strand rna virus surrounded by lipid membrane which is studded by envelope proteins to help it invade body. Hiv has 15 proteins and will be able to rearrange cell function so that it becomes a viral production factory. Replication cycle: binding & fusion: to cd4 cells, infection, reverse transcription: virus rna inserted into dsdna, integration (now basically a gene in your cell): viral dna combined with host. Dna: transcription: long chains of protein made from viral dna, assembly: chains of viral protein, maturation: proteins combine to make new functioning virus. Host immune response to hiv: innate response.
