HSCI 130 Lecture Notes - Lecture 15: Clonal Anergy, Nontuberculous Mycobacteria, Flast V. Cohen

• School: Simon Fraser University
• Department: Health Sciences
• Course: HSCI 130
• Professor: Rochelle Tucker

Document Summary

Begins with latent infection, and then exposure to tb bacillus. Usually affects the lungs and respiratory tract. Tb can affect other organ systems in the body. Systemic infection when lymphatic dissemination spreads tb bacilli throughout body. Bad cough that lasts longer than 2 weeks. Slow growing; generation time (approximately 24 hours) High molecular weight of lipids in their cell walls. Genetic mapping has indicated that bacteria not a mutation of m. bovis (theory that was held until 10 years ago) Million years ago in soil and water in paleolithic period. Traces identified in egyptian mummies from 3500-400 bc. Established in north america by the early 1700s. Largely unknown in africa at the beginning of 1900s spread with european colonization. Formula: true positives/number with disease x 100% Decreasing false negatives (with disease tests negative) will increase proportion of true positives. Disease will progress to severe form without treatment. Formula: true negatives/number with disease x 100%