HSCI 100 Lecture Notes - Lecture 16: Ureteric Bud, Underarm Hair, Kidney Development
21 Jan 2017
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Hsci 100: lecture 16: development, puberty, and aging. In multicellular organisms, most cells specialize and differentiate (proliferation, interaction, specialization, movement) Morphogen: agent that causes morphogenesis during development. Teratogen: agent that causes abnormal development in utero. Mutagen: agent that causes permanent change in dna sequence. Pathogen: agent that ca uses infectious disease. Reciprocal interactions between cells can drive morphogenesis and differentiation. A great deal of development is about where and when, and much of it is due to local (paracrine) signaling. Vasculature supports lung epithelium, which supports vascularization. Neuritogenesis: growth of dendrites and axons can be spurred by secreted signals or growth factors. Synapse strength relies on electrical activity (action potentials) experience shapes physiology. Cells with input from the left and right eye are arranged in stripes in the visual cortex of the brain. One eye is kept covered during a critical window of development. Embryonic kidney development series of reciprocal inductions: mesenchymal to epithelial transformation.
