BISC 313 Lecture Notes - Lecture 34: Covalent Bond, Central Dogma Of Molecular Biology, Shortness Of Breath
10 Apr 2019
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Mutagenesis process of alterations in genetic material of an organism: occurs naturally, natural spontaneous mutations, evolution, changes in genome, also occurs due to chemical exposure. Slide on diseases due to mutagenesis: cystic fibrosis mutation in gene coding for cftr transporter, cystic fibrosis transmembrane conductance regulator. Ion channel, controls the flux of cl ion in epithelial cells. Two classes: gene mutations, alterations in the nucleotide sequence of a gene, chromosomal effects. Larger in scales, changes in chromosome structure or number: chemicals can affect both of these, pharmaceuticals, environmental contaminants. Dna replicates itself, transcribe to rna, then translate rna to get protein. Acridine and come in and make a covalent bond inside the dna, causes interference: can be non-covalent, you can have substitutions, insertions or deletions because of this. Deletions and insertions have more of a significant effect on protein: because deleting or inserting causes a frame shift. Animal has lots of cells, lots of organs, lots of dna.
