BPK 446 Lecture Notes - Lecture 10: Chemotaxis, Spliceosome, Comorbidity
15 Mar 2017
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Accounts for 5-15% of presenile dementia (<65 yrs: clinical findings reflect the area of brain affected with disease, younger age of onset than ad; mean survival time is approx. Ftd- clinical findings: men = women; length of disease 8 yrs; behavioural or speech problems; antisocial behaviour, inappropriate social or sexual behavior; three forms: 1) Behavioural-variant, and two dementias with speech impairment: 2) primary progressive aphasia and 3) semantic-variant dementia (semantic dementia: behavioral: behavioural variant ftd (bvftd) Change in executive function (due to frontal involvement: changes in personality, social behaviour, mental (cid:513)rigidity(cid:514) as well as inappropriate social and sexual behaviour, distractibility, and lack of insight. The (cid:513)bulbar(cid:514) muscles of the throat, tongue, jaw, and face are those supplied by motor nerves from the lower brain stem (cid:507)aka (cid:513)the bulb(cid:514) brainstem) which control swallowing and speech. Bulbar complaints consist of difficulty swallowing (dysphagia) or speaking (dysarthria) In additional, frontal lobe signs may be present.
