BPK 306 Lecture Notes - Lecture 19: Citric Acid Cycle, Phosphocreatine, Serca

• School: Simon Fraser University
• Department: Biomedical Physio & Kines
• Course: BPK 306
• Professor: Sam Doesburg

Document Summary

Muscle metabolism muscle requires atp for contraction. 5 main pathways supply atp to muscle: glycogen and glucose metabolism, lipid metabolism, phosphocreatine and purine nucleotides (purine is not important for this class) Muscle accounts for 25-45% of body mass and is an important organ". Muscle needs atp: atp is used to allow for cross bridge cycling, atp is needed for the na+/k+ exchanger. In the glycogenolysis pathway, we can get gene mutations in enzymes and defective pathway function. At rest: fatty acids are primary energy source, o2 is abundant and aerobic metabolism is used, glucose taken in is stored as glycogen, phosphor-creatine reserves are built up. Moderate activity: phosphor-creatine reserves are used first, but quickly used up, muscles then use aerobic metabolism of fatty acids and glucose released from glycogen stores to make more atp. Intense activity: muscle lacks o2 to support mitochondria.