BPK 205 Lecture Notes - Lecture 8: Axon Hillock, Saltatory Conduction, Repolarization

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Discuss the threshold and initiation of action potentials. Threshold is reached when the total of graded potentials is above -55mv. Spatial summation of graded potential: occurs when currents from nearly simultaneous graded potentials combine. Inhibitory postsynatic potential (ipsp) may decrease the sum and prevent ap trigger. Temporal summation of graded potential: occurs when 2 graded potentials from one presynaptic neuron occur close together in time. Voltage-gated na+ and k+ channels: when the threshold point is reached at the axon hillock, nav channels open and more sodium rush in depolarization. Channel gating: activation, inactivation, deactivation: activation done by threshold membrane potential (-55mv), a gate opens and ions move through. Inactivation done by the peak membrane potential (+30mv), another gate closes the cha(cid:374)(cid:374)el a(cid:374)d io(cid:374)s ca(cid:374)"t (cid:373)o(cid:448)e through: deactivation done by rmp (-70mv), activation gate closes and deactivation gate opens. Recovered to starting stage that is ready for another action potential.

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