BPK 205 Lecture Notes - Lecture 4: Signal Transduction, Endoplasmic Reticulum, Phospholipase C

• School: Simon Fraser University
• Department: Biomedical Physio & Kines
• Course: BPK 205
• Professor: Nadine Wicks

Document Summary

Discuss modes of local vs long distance communication. Signals may affect the same cell that secreted them (autocrine) or the neighbouring cells (paracrine) Endocrine glands = make substance that will stay inside the body. Exocrine glands = make substance that will eventually leave the body (i. e. bile that gets dumped to feces) Major signaling molecules: glutamate, glycine, gaba (amino acid); epinephrine, Norepinephrine (amines); insulin, glucagon (peptides or protein); ca2+, acetylcholine (others) Name 3 types of membrane signaling receptors: ligand = a molecule that binds to a larger molecule. Enzyme-linked receptors: ligand binds to receptor activate associated enzyme. Ligand-gated channels: ligand receptor is an ion channel that is gated by ligand binding. Explain the major features of a signal transduction pathway. Receptors ligand binds to receptor initiation of series of intracellular responses; specific respo(cid:374)se of (cid:272)ell depe(cid:374)ds o(cid:374) re(cid:272)eptor"s asso(cid:272)iated sig(cid:374)al tra(cid:374)sdu(cid:272)tio(cid:374) path(cid:449)ay (cid:894)(cid:272)a(cid:374) (cid:448)ary between cells/tissues) Signaling cascades transduced signal activates a molecule which activates another molecule.