BPK 205 Lecture Notes - Lecture 6: Blood Sugar, Anterior Pituitary, Irreversible Antagonist

• School: Simon Fraser University
• Department: Biomedical Physio & Kines
• Course: BPK 205
• Professor: Nadine Wicks

Document Summary

Draw a simple endocrine reflex loop and give two specific examples (done on paper) Up/down regulation: (cid:272)ells" hor(cid:373)o(cid:374)e se(cid:374)siti(cid:448)ity adjust(cid:373)e(cid:374)t i(cid:374) respo(cid:374)se to (cid:272)ha(cid:374)ges i(cid:374) hor(cid:373)o(cid:374)e concentration; long-term effects that take time to occur: up-regulation: cells try to maintain response in low [hormone] Permissiveness: hor(cid:373)o(cid:374)e a (cid:272)a(cid:374)"t produ(cid:272)e full effe(cid:272)t (cid:449)ithout hor(cid:373)o(cid:374)e b = b is permissive for a: ex/ reproductive hormones (estrogen, testosterone) by themselves (a) delayed reproductive development; thyroid hormone (b) no reproductive development; a + b. Normal reproductive development: b does(cid:374)"t (cid:374)eed to ha(cid:448)e sa(cid:373)e effe(cid:272)t as a (cid:271)ut is required for a to work properly, molecular mechanisms unclear. Functional antagonism = hormones with opposite actions: ex/ insulin (decrease blood glucose) vs glucagon (increase blood glucose, do(cid:374)"t (cid:374)eed to share re(cid:272)eptors or sig(cid:374)alli(cid:374)g path(cid:449)ays. Primary ligand = ligand that is in the body and normally binds to the receptor.