BISC 300 Lecture Notes - Lecture 12: Allele Frequency, Meiosis, Pleurothallis

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List the fitness costs and benefits of sexual reproduction. Explain why recombination is important for generating genetic variation. Define linkage disequilibrium and relate the coefficient of ld to recombination. Describe why ld is important for our understand of selection. Discuss the two hypotheses for the short-term benefit of sex. If two loci are in linkage equilibrium, then under hw conditions, haplotype frequencies will not change from one generation to another. If instead, the loci are in ld, then haplotype frequencies will change across generations: hwe violated! Often, a sign of recent selection events. Indeed, strong selection at one locus can carry along (neutral or even deleterious) alleles at other loci that are on the same chromosome. This is called genetic hitchhiking; remember crohn"s disease example. Ld can help us identify alleles that have recently been favored by positive selection. If no selection for allele, then allele can be:

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