BISC 202 Lecture Notes - Lecture 22: Hydrogen Bond, Phosphodiester Bond, Diplococcus

• School: Simon Fraser University
• Department: Biological Sciences
• Course: BISC 202
• Professor: Carol Wenzel

Document Summary

Chapter 10: dna structure and analysis: the ge(cid:374)eti(cid:272) material must e(cid:454)hi(cid:271)it four chara(cid:272)teristi(cid:272)s, for a (cid:373)ole(cid:272)ule to ser(cid:448)e as the ge(cid:374)eti(cid:272) (cid:373)aterial, it (cid:373)ust (cid:271)e a(cid:271)le to: Allow variation by mutation: the (cid:272)e(cid:374)tral dog(cid:373)a of (cid:373)ole(cid:272)ular ge(cid:374)eti(cid:272)s is that dna (cid:373)akes rna, (cid:449)hi(cid:272)h (cid:373)akes protei(cid:374)s. Historical perspective: u(cid:374)til 19(cid:1008)(cid:1008), o(cid:271)ser(cid:448)atio(cid:374)s fa(cid:448)ored protei(cid:374) as the ge(cid:374)eti(cid:272) (cid:373)aterial why, e(cid:448)ide(cid:374)(cid:272)e fa(cid:448)ori(cid:374)g dna as the ge(cid:374)eti(cid:272) (cid:373)aterial (cid:449)as first o(cid:271)tai(cid:374)ed during the study of bacteria and bacteriophages. Griffith showed that avirulent strains of diplococcus pneumoniae bacteria could be transformed to virulence. Virulent strains had a polysaccharide capsule iiis. Avirulent strain has no capsule and makes rough colonies iir. Genes are associated with specific character traits. Mutations known to alter gene function, but the nature of mutations was not understood. Experiments involving transformation showed that dna was the genetic material. Nucleotides are the building blocks of dna: the(cid:455) (cid:272)o(cid:374)sist of: