BISC 101 Lecture Notes - Lecture 3: Nucleoside Triphosphate, Dna Replication, Nucleic Acid Double Helix

• School: Simon Fraser University
• Department: Biological Sciences
• Course: BISC 101
• Professor: Tony Williams

Document Summary

Dna replication: synthesis and repair: key concepts. Dna (nucleic acid) is the genetic material. Dna (cid:272)o(cid:374)tai(cid:374)s ge(cid:374)eti(cid:272) (cid:862)(cid:271)luep(cid:396)i(cid:374)t(cid:863) that di(cid:396)e(cid:272)ts the de(cid:448)elop(cid:373)e(cid:374)t of all (cid:271)io(cid:272)he(cid:373)i(cid:272)al, a(cid:374)ato(cid:373)i(cid:272)al, physiological and behavioural traits. You resemble you parents because of precise replication of dna and transmission from one generation to the next. The molecular structure of dna (cid:894)watso(cid:374) a(cid:374)d c(cid:396)i(cid:272)k"s dis(cid:272)o(cid:448)e(cid:396)(cid:455)(cid:895) p(cid:396)edi(cid:272)ts ho(cid:449) dna (cid:396)epli(cid:272)ates (and started genetic engineering) Many proteins work together in dna replication (e. g. : primase, helicase, polymerase) Specific details of replication process differ between the two dna strands that replicate (cid:894)(cid:862)leadi(cid:374)g(cid:863) vs (cid:862)laggi(cid:374)g (cid:862)strands) Dna replication is not perfect (repair mechanisms and telomeres: dna (deoxyribonucleic acid) and rna (ribonucleic acid) are polymers of nucleotide monomers. Dna has deoxyribose sugar + either c, g, a, or t. Rna has ribose sugar + c, g, a, or u: nucleotides polymerise to form nucleic acids. Nucleotides polymerize via a condensation reaction forming phosphodiester li(cid:374)k (cid:271)et(cid:449)ee(cid:374) (cid:1007)" (cid:272)a(cid:396)(cid:271)o(cid:374) a(cid:374)d 5" (cid:272)a(cid:396)(cid:271)o(cid:374)