PAT 20A/B Lecture Notes - Lecture 4: Ascending Limb Of Loop Of Henle, Aldosterone, Bradycardia

• School: Ryerson University
• Department: Pathotherapeutics
• Course: PAT 20A/B
• Professor: Susan Bishop

Document Summary

A- blocks the binding of angiotensin i to the active site of ace preventing its conversion to angiotensin ii. E- bp decreases due to the inhibition of angiotensin ii causing vasodilation and decreased aldosterone (enhancing na and. A- competitively antagonizes angiotensin ii by blocking its binding to at1 receptors. E- decreases bp due to vasodilation caused by the blocking of angiotensin ii at at1 receptors. A- blocks ca channels in systemic vascular and coronary vascular smooth muscle preventing the movement of ca ions across cell membranes. E- bp decreases due to vasodilation caused by the blocking of the ca channels, which prevents resting tone and contraction. A- inhibits the na-k-2cl co-transporter in the thick ascending limb portion of the loop of henle. Na, cl and h20 to the collecting duct increases, encouraging urinary elimination. A- blocks the na-cl co-transporter in the distal tubule, preventing reabsorption of these ions. E- decreases bp by means of decreased systemic vascular resistance.