PAT 20A/B Lecture Notes - Lecture 5: Adipocyte, Macrophage, Leptin

• School: Ryerson University
• Department: Pathotherapeutics
• Course: PAT 20A/B
• Professor: Beth Swart

Document Summary

Bmi classes: underweight: less than 18. 5, normal: 18. 5-24. 9, overweight= 25-29. 9, obese, class i: 30-34. 9, class ii: 25- 39, morbidly obese (class iii): 40 and above. Significance of obesity: metabolic syndrome -> dmii -> cv disease, therefore, low self-esteem, weight loss/ weight stigma/ social and employment discrimination, negative attitudes and stereotypes. Causes: drugs, thyroid disorder, cushing syndrome, and pcos, genes plus biology influenced by environment and psychosocial factors, obesogenic diet, physical inactivity, psychosocial factors, social determinants, lower ses (women) and, poverty. Higher ses (men: food insecurity, lower education. *sugar should be less than 10% of daily energy intake (50g or 12 tsp for adults) * Ghrelin and leptin: stretch receptors in stomach activate sensory afferent pathways in the vagus. Inhibits food intake: glp-1, cck, and insulin are released to supress feeding, ghrelin is released to stimulate appetite, leptin is produced by fat cells as fat cells increase in number and size.