NSE 22A/B Lecture Notes - Lecture 7: Intravenous Therapy, Blood Transfusion, Blood Plasma
22 Feb 2020
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4 components of body fluid: h2o (60%, dissolved particles, electrolytes, non-electrolytes, blood. Ecf- 2 smaller compartments: transcellular perineral, fluid in gi tract. Intravascular blood plasma ph: concentration of h+ in solution, neutral ph 7. 35 -7. 45 normal serum, acid ph < 7. 35, base ph > 7. 45, high h+ = acid, low h+ = base. Osmosis, osmolality & osmolarity (better explanation on patho ppt: osmosis, movement of water molecules from region of high water concentration to low water concentration, osmolality (concentration of dissolved particles inside the body (in the blood). Crystalloids: small molecules that diffuse through capillary walls, depending on solute concentration, fluids may be, isotonic, hypertonic, hypotonic, hypertonic fluid imbalance will in general receive a hypotonic intravenous solution, most commonly used, b/c closest to body osmolality. Colloids: larger molecules cannot diffuse through capillary walls, stay in vascular system, blood & blood products, 5% albumin, fresh frozen plasma (ffp, synthetic colloids, dextran, pentaspan, voluven.
