NSE 22A/B Lecture 8: WEEK EIGHT- BLOOD TRANSFUSION
17 Jan 2019
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4 main components: plasma, red blood cells, white blood cells, platelets. Types of transfusions available: whole blood, packed red blood cells (prbc, platelets, albumin (5% or 25%, fresh frozen plasma (ffp, cryoprecipitate, ivif (intravenous immunoglobulins) Nb blood products only compatible with normal saline (except for ivig) Do not add any drugs or addititves to blood products. Whole blood: whole blood or packed cells are transfused where major blood loss occurred. Packed red blood cells (prbcs: most commonly used, once plasma has been removed from whole blood, additives are used to re-suspend red cells (maintain red cells in optimum condition during storage) Indications: rbcs improve oxygen carrying capacity, useful as a volume expander after acute blood loss, symptomatic anemia. Platelets: dynamic protein in plasma responsible for maintaining the plasma colloid osmotic pressure thereby regulating intravascular blood volume: responsible for clotting (coagulation), change fibrinogen into fibrin, creates a mesh onto which red cells collect and clot.
