FNN 202 Lecture Notes - Lecture 4: Brain-Derived Neurotrophic Factor, Gut Flora, Neuroplasticity
19 Jul 2020
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Effects of coffee ranges per person depending on their genes: gene: cyp1a2, which controls an enzyme and also cyp1a2 that controls how quickly our body breaks down caffeine. 4+ cups of coffee a day= risk of heart attack increased by 36: heavy coffee consumption only seemed to be linked to a higher likelihood of heart attacks in the slow metabolizers. The increased risk that we saw among the entire population was driven entirely by the people that were slow metabolizers," no risk for fast metabolizers . The trend among fast metabolizers was quite the opposite. But fast metabolizers clear caffeine from their systems rapidly, allowing the antioxidants, polyphenols and coffee"s other healthful compounds to kick in without the side effects of caffeine, he said. Heavy and even moderate coffee drinkers were significantly more likely to have hypertension if they were slow metabolizers. But fast metabolizers saw their risk of hypertension fall as their coffee intake rose.
