BMS 870 Lecture Notes - Lecture 2: Amyloid, Neurofibrillary Tangle, Axon Hillock
28 Oct 2017
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Document Summary
Paper on any aspect of neurobiology that you are interested in. Clinical trials: testing drugs on humans that have been found to be effective on cells (hela cells, neuronal cells) Phase 1 - small number of healthy people. Phase 3 - several thousand (most 8605$) - double bind trials - test subject and administrator don"t know that they"re getting the trial. Microtubules - tubulin 20 nm diameter; organized by maps; tau is a map that is implicated in alzheimers. Road tracks for cell trafficking all the way down axon. Microfilaments - actin filaments are 5 nm; numerous in neurites. Neurofilaments of intermediate filaments are 10 nm diameter. Alzheimer"s accumulation of amyloid -> neurofibrillary tangles -> dementia. Axon hillock - decide on ap (arrows - track of axon and signalling) Differences bw axon and soma - er doesn"t extend into axon = few ribosomes; unique protein composition. Axon terminal (end - where you release nt).
