BMS 451 Lecture Notes - Lecture 18: Orchitis, Flu Season, Antigenic Shift
13 Dec 2016
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Document Summary
Lecture 18- respiratory viruses viral infections of the respiratory tract. The respiratory tract is the leading site of viral infection in the body. Most infections are minor, although novel disease outbreaks still occur occasionally. Rhinovirus, coronavirus, influenza, parainfluenza, measles (disseminating virus), respiratory syncytial virus rhinovirus- the common cold icosahedral structure, reduced genome. Typically causes a mild upper airway infection. Replication is temperature limited to 33-35 c- only get infection of upper airway due to temp. Capsid composed of four viral proteins (vp1-4) Exhibit exceptional diversity, results in decreased immunity entry. Receptor is icam-1 in 90% of viruses and vldl receptor for 10% Conformational shift of capsid followed by release of rna genome rhinovirus cuts up and rearranges its rna to encode for different proteins spread and multiplication. Due to temperature restriction of the virus, infectious cycle continues to adjacent cells. Incubation period is 1-4 days and viral shedding peaks after 2-3 days.
