BLG 311 Lecture Notes - Lecture 10: Glycerophospholipid, Cell Nucleus, Caveolin
18 Sep 2018
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Document Summary
Presence of both a polar end and a non polar end=amphiphilic (all cell membranes are. Main phospholipid in animal cell membrane are phosphoglycerides. Cholesterol is a sterol rigid structure+single polar oh group short non polar hydrocarbon chain. Liposomes: synthetic arti cial lipid bilayer, 2 rows of phospholipids, used for drugs delivery. Plasma membrane top layer=> outer lea et faces extracellular space second row facing cytosol=inner lea et not identical. Saturated: more rigid, less space between tails unsaturated(more uid, presence of double bonds, introduces bent in structure of hydrocarbon tail. Lipid raft region in bilayer heavily concentrated with cholesterol, sphingolipids and certain proteins novel phenomena before 10-12 years ago didn"t understand example: caveolae(look like little cave) Caveolae face cytoplasmic side form because of in ating lipid bilayer high amount of caveolin kinases=> phosphorylates protien kinase (needs ps to activate) phospholipid translocators rapidly increases time of transportation.
