PHGY 214 Lecture Notes - Lecture 6: Metabolic Acidosis, Diabetic Coma, Insulin Resistance
28 Apr 2016
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Document Summary
Diabetes mellitus is a condition of inadequate insulin secretion that leads to chronic hyperglycemia (too much glucose: not enough insulin to maintain glucose within normal range. The two types of diabetes mellitus (sweet) are: type 1 - characterized by insulin absolute deficiency (complete loss) Autoimmune destruction of cells of pancreas. Vast majority occurs in adolescence: type 2 - known as insulin-resistant diabetes. Occurs primarily in obese: obesity rate is 90% There is a third type: incipidus (don"t need to know) Type 1 or insulin dependent diabetes: juvenile onset diabetes, due to loss of insulin production, requires insulin (first hormone isolated in 1921) Pig insulin, bovine insulin, synthesized by recombinant technology: injected. Type 2 or insulin independent diabetes: adult onset diabetes (often associated with obesity) No longer adult onset, some adolescents are starting to get it: insulin levels are high but not high enough. Insulin resistance: boost insulin production or reduce insulin demand through life style modifications.
