PHAR 340 Lecture Notes - Lecture 30: Cromoglicic Acid, Prostaglandin D2, Beclometasone Dipropionate
23 Dec 2018
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Document Summary
Inflame of airways + incr resistance to airflow due to contraction of bronchiolar smooth muscle, mucosal edema, bronchiolar secretions. Characterized by: shortness of breath, tight chest, cough, wheezing pulm test conducted. Potential therapeutic targets= transc factors, anti-ige, cytokine inhibitors, mediator antagonists. Mast cell his prod ltc4, paf + pgd2 cytokines that recruit eosin + neutrophils (inflame) thickening of airway walls. Inhaled irritants: detected by sensory r vagal afferent cns integration vagal efferent postgang neuron to release tachykines + sub p to incr smooth muscle contraction. Admin via inhalation (2-5um) so its delivered to site of action w lowest possible doses to min effects on non-target tissues, only 10-20% inhaled and 80-90% subjected to first pass in liver. Acute for termination of attack and prophylactic for prevention. First take saba + low dose ics then w higher dose ics laba ltra anti-ige.
