PHAR 340 Lecture Notes - Lecture 19: Cardiogenic Shock, Ritodrine, Terbutaline

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 340
• Professor: Thomas Massey

Document Summary

Nasal decongestant, elevates systemic bp to combat hypotension. Antihypersensitive, acts presynaptically to reduce ne release, cns effects. High conc act vascular a2 rs vasoconstriction + incr bp. B2: aka ventolin, terbutaline, used in puffers for asthma, decr bp slightly. 2000 yrs of use in china, found in various plants, direct and indirect effects. B + a agonist and incr release of n, long duration of action, low potency. First act heart rs to incr hr then act b2 rs in skeletal muscle to act vasodilation and decr. Amphetamines use ne transporters and sucked into nerve terminal and taken up into vesicular transporter reversing transporter direction and pumping out ne + other amines (5-ht, dop) Potent cns effects, peripheral effects similar to adrenergic agonists, modafinil used to treat narcolepsy, methylphenidate for adhd. Act b1 in heart, a1 in peripheral vasculature. Overall= slight incr in bp, no change if admin w a1 antagonist.