PHAR 230 Lecture Notes - Lecture 1: Agonist, Partial Agonist, Bradykinin Receptor B2

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 230
• Professor: Hisham Elbatarny

Document Summary

Drug-body interactions: interactions btwn a drug and the body can be divided into two main groupings: Pharmacodynamics: actions of the drug on the body. Pharmacokinetics: actions of the body on the drug. To achieve a beneficial effect on the indv by modifying a functional process. E. g. taking a drug to dilate blood vessels to decrease blood pressure. To exert toxic effect on a invading parasite or organism. E. g. taking antibiotic to kill bacterial infection. selective toxicity: the use of drugs to harm invading organism w out harming the host. Want beneficial effect: drug does(cid:374)"t do a(cid:374)ythi(cid:374)g (cid:374)e(cid:449) It modifies homeostatic functional properties of the body: modifies something that already exist, e. g. Take drug to dilate blood vessels for htn. Toxic effect on invading organism: aimed at organism vs mammalian cell, known as selective toxicity. Nature of drugs: receptors: most drugs influence biological systems by interacting w specific macromolecule that has functional role in homeostatic processes of the system.