PHAR 100 Lecture Notes - Lecture 11: Medial Forebrain Bundle, Reticular Formation, Dextroamphetamine

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Nikki Philbrook

Document Summary

Describe the mechanism of action of amphetamines and cocaine. Discuss the response to various doses of amphetamines and cocaine. Describe the methods used to administer illicit cocaine and amphetamines. Explain the dependence liability of cocaine and amphetamines. State the differences in response to cocaine and amphetamines. Includes dextroamphetamine, methamphetamine, and other designer drugs such as mda, and ritalin. 1945: advertised as an appetite suppressant in the usa. 1960: outbreaks of abuse in canada, sweden, and usa. 1973: classified as a controlled substance in canada and used for medical purposes. Methamphetamine produces more central stimulation and less sympathetic compared to amphetamine. Release norepinephrine and dopamine for an excitatory response. Binds to the dopamine transporter (dat) and are taken up into the dopaminergic nerve terminal where it blocks the packaging of dopamine into the vesicles by the vesicular monoamine transporter (vmat) This results in lots of dopamine in the neuron that can flow out of the cell through the dat.