PATH 310 Lecture 10: Intro to Cancer I
20 Mar 2017
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Document Summary
Neoplasm: a collection of abnormal cells that divide without control, benign neoplasm: does not invade or spread (smooth round border, malignant neoplasm: cancer, invades or spreads to other tissues (wavy extensions) Metastasis: spread of cancer cells to new areas of the body through the bloodstream, almost every cancer that can invade can metastasize. Cancer is a genetic disease: risk factors increase genetic damage, radiation (uv, other, tobacco, human papilloma virus, western diet, age. Hallmarks of cancer: all cancers share six common traits (hallmarks) that govern the transformation of normal cells to cancer (malignant or tumor) cells: Insensitivity to anti-growth signals: self sufficiency in growth signals, evading apoptosis, sustained angiogenesis (formation of new blood vessels, tissue invasion and metastasis, limitless replicative potential. Benign tumours: benign tumours have 5 of the 6 hallmarks, they do not cause cancer because they do not invade:
