MICR 360 Lecture Notes - Lecture 24: Cd28, Icam-1, Beta Sheet

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Tcr by itself is non-functional, needs to bind something to do signalling. Upon antigen presenting in mhc, several signal conduction pathways is transduced in t cell => if helper. T, will make cytokines; if killer t, will make products for killing. Tcr binding to mhc is low interaction compared to antigen binding to ab. Need other partnering mlcls to help stabilize interaction b/w tcr and mhc. 3 step pathway: signal i antigen specific tcr engagement. Interaction b/w apc presenting antigen in context of mhc: signal ii interaction w/ cd28 (not cd4 or cd8, signal iii cytokines which is induced by apc, can have paracrine interaction (ex. Il-12 can be produced by macrophage and bind to t cell; can also have autocrine that activates same t cell that made cytokine) Early responses are positive co-stim and are sent to t cell to tell them to get activated.

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