MICR 221 Lecture Notes - Lecture 26: Internal Ribosome Entry Site, Papillomaviridae, Double-Stranded Rna Viruses
1 Jan 2016
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Document Summary
Dna/rna can be released by gently cross-linking and spreading under conditions that tend to disrupt capsids. Reovirus (which contains 10 internal dsrna segments), is shown. Levels of regulation of gene expression eukarya all potential targets for virus regulation of host gene expression to enhance virus gene expression. Virus modi cation of host systems: examples use rna splicing to compress more genetic information into genomes eg. adenoviridae, Dna genome replication: double-stranded dna viruses (section 25. 2), two groups, replication exclusively nuclear. Double strand (ds) dna viruses: reminder: virus family names end in -viridae, examples: polyomaviridae, baculoviridae, papillomaviridae, adenoviridae and herpesviridae genome transcribed and replicated in the nucleus and can use the host transcriptional machinery. Virus gets its dna up to the nuclear membrane and injects dna into the nucleus. Dna circularizes once gets into host nucleus (originally linear) Helps w/ transcription and translation: no ends. Late: structural (associate w/ viral dna) early dsdna virus replication recognize.
